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Frank D. Gray, JR, MD; Alfred Soffer, MD

JAMA. 1980;243(21):2190-2191.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Now is a good time, as we finish one decade and start a new one, to take stock of how internal medicine has fared. But to identify the single most important idea or event of a decade is a task I face with considerable awe. However, one outstanding trend has been the redirection of our focus from organs and tissues to cells. The change began long before the 1970s, but it became pervasive during this decade. Cellular and molecular biology is now a clinical reality to the physician at the bedside.

The biologic concept of the cell has been with us more than two centuries, and the idea that the cell is a focus of disease germinated at approximately the time Virchow published his treatise on cellular pathology slightly more than 100 years ago. The first half of the 20th century saw little progress in clinical concepts of the cell, . . . [Full Text PDF of this Article]

Author Affiliations
Philadelphia; Park Ridge, III

From the Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia.; Member, editorial board, The Journal.

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