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Prophylaxis With Hepatitis B Immune Globulin

Massumeh Telischi, MD; Mahin Ziyai, MD; Frederick Steigmann, MD; Chung Mei Ling, PhD

JAMA. 1980;244(20):2312-2313.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A STUDY by Seeff and colleagues¹ established the effectiveness of hepatitis B immune globulin (HBIG) for immune prophylaxis in persons exposed to known infectious inocula. Studies in other laboratories^2-4 also showed effective protection by HBIG in preventing or delaying overt viral hepatitis B after accidental exposure to hepatitis B virus (HBV). Accordingly, prophylactic injection of HBIG for persons working in high-risk environments was recommended. The Public Health Service Advisory Committee on Immunization Practice recommended a two-dose schedule of HBIG treatments for individuals exposed to a single inoculum of hepatitis B surface antigen (HBsAg)-contaminated material.⁵ A study by Klein et al⁶ supported the two-dose schedule, rather than a single dose, when the initial dose of globulin was the same.

We describe a patient who was effectively treated with HBIG after being accidentally transfused with a unit of HBsAg-positive plasma. At the time we were not aware of a . . . [Full Text PDF of this Article]

Author Affiliations
From the Blood Bank (Drs Telischi and Ziyai) and the Division of Gastroenterology (Dr Steigmann), Cook County Hospital, Chicago; and the Virology Laboratory, Abbott Laboratories, North Chicago (Dr Ling).

Footnotes
Reprint requests to Blood Bank, Cook County Hospital, 1825 W Harrison St, Chicago, IL 60612 (Dr Telischi).

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