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Thomas W. Bodendorfer, PharmD
Memorial Hospital Medical Center Long Beach, Calif

JAMA. 1980;244(23):2609.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Acute interstitial nephritis caused by any drug is probably a rare drug reaction. Methicillin sodium is the most commonly reported penicillin derivative associated with nephritis, with more than 100 cases being reported.¹ Reexacerbation (ie, cross sensitivity) with nafcillin, ampicillin, and cephalothin administration has been reported (1973;225: 178; 1974;227:255).² Although histological confirmation was not obtained, this is a probable case of nafcillininduced interstitial nephritis.

Report of a Case.—

A 60-year-old man was admitted to the orthopedic unit of Memorial Hospital Medical Center with a painful swollen right knee. He had a 40-year history of hypertension, rheumatoid arthritis, and coronary artery disease, but no renal disease. Therapy with indomethacin, 100 mg/24 hr, and allopurinol, 200 mg/24 hr, was started. Medications continued from before admission included propranolol hydrochloride, 160 mg/24 hr, isosorbide dinitrate, 160 mg/24 hr, and nitroglycerin as needed.

On the second day of hospitalization, knee aspirate . . . [Full Text PDF of this Article]

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