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Guy Decaux, MD; Jacques Unger, MD; Jean Mockel, MD, PhD

JAMA. 1980;244(6):589-590.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE SYNDROME of inappropriate secretion of antidiuretic hormone (SIADH) can occur in various CNS disorders.¹ Generally, the syndrome disappears when the underlying cause is treated, but treatment can be long or sometimes fails. Symptomatic treatment is necessary for rapid correction of hyponatremia when neurological manifestations are present. The treatment usually recommended is hypertonic saline with or without furosemide.² For long-term management of SIADH, water restriction or demeclocycline is used.³ As urea is known to decrease brain edema⁴ and to induce osmotic diuresis,⁵ a patient with SIADH secondary to tuberculous meningitis was treated with this drug. Administration of urea rapidly corrected the neurological symptoms and hyponatremia and also proved useful for the long-term management of SIADH despite large fluid intake.

Report of a Case

A 52-year-old man was admitted because of headache. Meningeal signs were present. The computerized tomographic brain scan, funduscopic findings, and chest roentgenogram . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Internal Medicine, St Pierre University Hospital, and the Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, University of Brussels.

Footnotes
Reprint requests to Department Médecine Interne, Hôpital Universitaire St Pierre, Rue Haute 322, B-1000 Brussels, Belgium (Dr Decaux).

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