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Walter E. Stamm, MD

JAMA. 1980;244(6):591-592.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Based on the rationale that (1) cystitis is a superficial mucosal infection pathologically, (2) successful treatment of bladder infections depends on antibiotic levels achieved in urine, and (3) many antibiotics achieve very high urinary concentrations, the concept of treating acute cystitis with a single-dose antibiotic regimen has been attractive to physicians for years. The observation that a single irrigation of the bladder with neomycin sulfate cures many patients with bladder bacteriuria further suggested that brief drug therapy might well be effective. Unfortunately, early attempts to use single-dose sulfonamides, streptomycin sulfate, and cephaloridine were not uniformly successful. Inclusion of patients with chronic infections, unrecognized upper-tract involvement (localization studies were not usually done), and drug-resistant organisms may have contributed to single-dose treatment failures. However, in 1967 Grüneberg and Brumfitt¹ cured 88% of infections judged clinically to be cystitis with a single, 2-g dose of sulfadoxine (sulphormethoxine). Subsequently, Ronald et al,² . . . [Full Text PDF of this Article]

Author Affiliations
University of Washington Seattle

Footnotes
Address editorial communications to the Editor, 535 N Dearborn St, Chicago, IL 60610.

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