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Arye Lev-Ran, MD, PhD
Scripps Clinic and Research Foundation La Jolla, Calif

JAMA. 1981;245(10):1027.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Jacobson et al (1980;243:733) and Shroff and Jones (1980;244:658) recently stressed the differences between various thyroxine (T₄) preparations. Equally important are differences between preparations and batches of desiccated thyroid and thyroglobulin. The ratio of levothyroxine sodium to liothyronine sodium in the Armour Thyroid (desiccated thyroid) is 4.3; in Proloid (thyroglobulin), 2.9. Both preparations are sometimes more potent than claimed.¹ Generic thyroid preparations have variable T₄ and triiodothyronine (T₃) content (1980;243:549).² As a result, sometimes the patients treated with such preparations have development of thyrotoxicosis with normal T₄ and high T₃ levels. We observed this in 28 adults (27 of them women) aged 18 to 70 years. Blood was drawn in the morning, 24 hours after the previous dose; in view of the short half-life of T₃ in the blood, this could only underestimate the degree of hypertriiodothyroninemia. . . . [Full Text PDF of this Article]

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