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Richard M. Bergenstal, MD; Arthur H. Rubenstein, MD

JAMA. 1981;245(7):735-736.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Whether good metabolic control can delay or prevent long-term microvascular complications in diabetes remains to be proved in man, despite the accumulation of a substantial amount of evidence supporting this viewpoint.^1,2 The difficulty in obtaining conclusive data to answer this question in man is threefold. First, methods to quantitate accurately the degree of glucose control over a prolonged period have not been available, although the recent development of the glycosylated hemoglobin (Hb A_1c) assay,³ which reflects an integrated value of blood glucose over the preceding weeks to months, may partly solve this problem. The second difficulty has been the lack of reproducible and specific techniques to assess quantitatively specific diabetic complications at an early stage. However, advances are being made in this area.⁴ Third, it has been almost impossible to maintain prolonged normoglycemia, which might be a necessary condition to prevent the development of diabetic complications, . . . [Full Text PDF of this Article]

Author Affiliations
University of Chicago

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