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Phillip J. Olsson, MD
University of Illinois Peoria School of Medicine

JAMA. 1981;246(10):1087.

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To the Editor.—

Landwehr et al in their article "Rapidly Progressive Glomerulonephritis in Behçet's Syndrome" (1980;244:1709) reported what they believed to be the second biopsy specimen-proved case of glomerulonephritis in Behçet's syndrome. Actually, their case now brings the total to five cases in the English literature. In addition to Landwehr et al, Kansu et al (1977;237:1855), Mace and Jones,¹ Gamble et al,² and Olsson et al³ have described basically two patterns of glomerulonephritis. Four of five have had a diffuse proliferative glomerular lesion with variable but prominent crescent formation. Gamble et al² have reported a focal segmental glomerulonephritis. Each of the previously reported cases has had some element of fibrinoid necrosis present (albeit not prominent in the case reported by Olsson et al³). This corresponds with the pathogenesis of the disease as a vasculitis.⁴ Gamble et al² demonstrated circulating immune complexes in addition . . . [Full Text PDF of this Article]

Footnotes
Edited by John D. Archer, MD, Senior Editor.

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