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Robert H. Gerner, MD; Sheldon M. Wolff, MD; Anthony S. Fauci, MD; Robert P. Aduan, MD

JAMA. 1981;246(14):1584-1586.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THERE are several well-described, although not necessarily distinct, febrile, noninfectious, recurrent illnesses with normal-intervening intervals as follows: intermittent hydrarthrosis, familial Mediterranean fever (FMF), cyclic neutropenia (cyclic hematopoiesis), and periodic hypothalamic discharge. Although many of these disorders have been recognized for years, they are often misdiagnosed and frequently are discovered only after long and difficult diagnostic evaluation.¹ No specific origins characterize these disorders, and effective drug therapy is available for only two of these disorders: colchicine for FMF² and prednisone for cyclic neutropenia.³ We report a case of recurrent fever and neutropenia that responded to therapy with lithium carbonate.

The control of human body temperature is complicated and has recently been reviewed.⁴ In patients with recurrent fevers, the following causes might be found: abnormal production or release of endogenous pyrogen from host phagocytic cells; abnormalities of the hypothalamic thermoregulatory center's response to endogenous pyrogen; or abnormalities of . . . [Full Text PDF of this Article]

Author Affiliations
From the Section of Psychobiology, National Institute of Mental Health (Dr Gerner) and the Laboratories of Clinical Investigation (Drs Wolff and Aduan) and Immunoregulation (Dr Fauci), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. Dr Gerner is now with the UCLA Neuropsychiatric Institute, Los Angeles. Dr Wolff is now with the Tufts-New England Medical Center, Boston. Dr Aduan is now with the Veterans Administration Hospital, Fresno, Calif.

Footnotes
Reprint requests to UCLA Neuropsychiatric Institute, 760 Westwood Plaza, Los Angeles, CA 90024 (Dr Gerner).

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