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Guru P. Chatterjee, MD

JAMA. 1981;246(14):1589.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

NONSTEROIDAL anti-inflammatory drugs have been reported to cause a variety of renal diseases ranging from acute renal failure to nephrotic syndrome. I have seen a patient with nephrotic syndrome associated with tolmetin sodium.

Report of a Case

A 55-year-old woman with seronegative rheumatoid arthritis began therapy with 15 to 18 tablets of aspirin (5 grains each) in August 1977. She continued to have pains and stiffness and had thought of retiring at the age of 52 years. In August 1978, dosage was decreased to 12 tablets per day, and therapy with tolmetin sodium, 400 mg orally three times a day, was started, with excellent clinical results. In March 1980, she had ankle edema, and urinalysis showed proteinuria (4+) (dipstick; tetrabrom phenyl blue, confirmed with sulfosalicylic acid), many RBCs, and one to two WBCs per high-power field. Physical examination findings were unremarkable except for the ankle edema. Laboratory determinations disclosed the . . . [Full Text PDF of this Article]

Author Affiliations
From the Departments of Medicine and Nephrology, Hawaii Permanente Medical Group Inc, Honolulu.

Footnotes
Reprint requests to Department of Medicine, Hawaii Permanente Medical Group Inc, 1697 Ala Moana Blvd, Honolulu, HI 96815 (Dr Chatterjee).

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