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TolmetinAssociation With Reversible Renal Failure and Acute Interstitial Nephritis
Sheila Moriber Katz, MD;
Ralph Capaldo, MD;
Erich A. Everts, MD;
John G. DiGregorio, MD
JAMA. 1981;246(3):243-245.
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FENOPROFEN calcium and naproxen, nonsteroidal anti-inflammatory agents derived from proprionic acid, are linked to nephrotic syndrome, reversible renal failure, and acute interstitial nephritis.1,2 We present here a case of reversible renal failure and acute interstitial nephritis in a patient treated with tolmetin sodium (Tolectin), a nonsteroidal anti-inflammatory agent.
Report of a Case
A 70-year-old woman was admitted to the hospital because of nausea, anorexia, muscle weakness, and decreased urine output of two weeks' duration. She had mild hypertension for 30 years and mild osteoarthritis for ten years. Medications were as follows: methyldopa-hydrochlorothiazide (Aldoril), 25 mg three times a day for 15 years, prazosin hydrochloride (Minipress), 1 mg twice a day for two years, and tolmetin sodium, 200 mg three times to four times a day for three months.
Physical examination on admission showed blood pressure to be 150/90 mm Hg. Heart rate was regular at 80 beats per minute.
. . . [Full Text PDF of this Article]
Author Affiliations
From Hahnemann Medical College and Hospital, Philadelphia (Drs Katz and DiGregorio), St Mary's Hospital, Langhorne, Pa (Drs Capaldo and Everts), and Thomas Jefferson University, Philadelphia (Dr Everts).
Footnotes
Reprint requests to Hahnemann Medical College and Hospital, 230 N Broad St, Philadelphia, PA 19102 (Dr Katz).
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