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Suprasellar Pituitary Enlargement and Regression on Computed Tomographic Scanning

Bradd J. Silver, MD; Joseph L. Kyner, MD; Arthur R. Dick, MD; C. H. Joseph Chang, MD, PhD

JAMA. 1981;246(4):364-365.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE ASSOCIATION between primary hypothyroidism in adults and pituitary enlargement was first described in 1892.¹ Similar cases have been reported recently.^2-5 They have been characterized by enlargement or alteration in contour of the sella turcica. A decrease in pituitary size following thyroxine (T₄) replacement therapy has been reported by Jawadi et al,⁶ who demonstrated regression of suprasellar expansion with pneumoencephalography, and by Pita et al,⁷ who reported disappearance of a pituitary tumor on computed tomographic (CT) scan.

A case of suprasellar extension of pituitary tissue in a patient with severe hypothyroidism has been easily demonstrated by CT scanning using both transverse and coronal sections. The unusual feature of the case is that no abnormalities were noted on sella tomography. With supervised T₄ replacement, the CT changes completely resolved within two months.

Report of a Case

A 23-year-old woman was admitted for right optic neuritis. . . . [Full Text PDF of this Article]

Author Affiliations
From the Departments of Medicine (Drs Silver and Kyner), Neurology (Dr Dick), and Diagnostic Radiology (Dr Chang), University of Kansas Medical Center, Kansas City.

Footnotes
Reprint requests to Division of Endocrinology, 413-C, University of Kansas Medical Center, 39th and Rainbow Boulevard, Kansas City, KS 66103 (Dr Kyner).

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