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Khalid K. Muhalwas, MD; Gaurang M. Shah, MD; Robert L. Winer, MD

JAMA. 1981;246(8):867-868.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THERE is increasing awareness that long-term abuse of various analgesic agents is a major factor in the pathogenesis of renal papillary necrosis (RPN), which is an important cause of renal dysfunction. We describe a patient who experienced RPN while taking large doses of pentazocine in association with aspirin.

Report of a Case

A 49-year-old white man was admitted to the Long Beach (Calif) Veterans Administration Medical Center in October 1978 with a two-day history of lower abdominal pain radiating to both flanks. The pain was partially relieved by position change and was associated with nausea and vomiting. The only other symptom was passage of tissue via the urethra. A similar episode had occurred in August 1978. An excretory urogram obtained in April 1978 for evaluation of weight loss was normal. History included chronic alcoholism with hepatic cirrhosis, chronic pancreatitis, chemical diabetes mellitus, and cholelithiasis. He had been taking aspirin (1.8 . . . [Full Text PDF of this Article]

Author Affiliations
From the Medical Service, Veterans Administration Medical Center, Long Beach, Calif, and the Department of Medicine, University of California, Irvine.

Footnotes
Reprint requests to Nephrology Section, 111 N, Veterans Administration Medical Center, 5901 E Seventh St, Long Beach, CA 90822 (Dr Winer).

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