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T. J. H. Clark, MD, FRCP
Guy's Hospital London

JAMA. 1982;248(12):1449-1450.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

I was interested to read the answer given by Dr Irwin Polk to a question concerning the hazards of long-term use of inhaled beclomethasone, which appeared in THE JOURNAL. This inhaled steroid has been used in the United Kingdom since 1972 and is available for prescription in more than 100 countries throughout the world. Its sales during the past decade suggest that more than 4 million patient-years of experience has been gained with this drug and, indeed, more than 500 clinical trials have been reported. The safety of inhaled beclomethasone has been well established by worldwide experience, and I know of no reports of clinically important systemic side effects from its treatment. It is true that with sensitive tests some systemic activity can be observed during therapy,¹ but most studies have shown that plasma cortisol levels and response to adrenal stimulation remains intact unless the dose of . . . [Full Text PDF of this Article]

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