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Nobuhisa Baba, MD, PhD; James J. Quattrochi, PhD; Charles B. Reiner, MD; William Adrion, MD; P. Terry McBride; Allan J. Yates, MD, PhD

JAMA. 1983;249(20):2789-2791.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE INCIDENCE of sudden infant death syndrome (SIDS) is approximately one to three per 1,000 live births. Recently, the Health Service Administration has estimated that 6,500 to 8,000 SIDS cases occur annually in the United States, accounting for almost 40% of the total infant mortality.¹ Sudden infant death syndrome is the single largest cause of death between the ages of 2 weeks and 1 year, with the peak incidence between 2 and 4 months of age.

Clinical observations of SIDS and near-miss SIDS infants have implicated a respiratory control dysfunction. Infants observed to be apneic for 20 s or longer, possibly requiring resuscitation, are termed near-miss for SIDS.² Studies of these infants have examined such factors as periodic breathing,³ prolonged apnea,⁴ sleep states,⁵ arousal threshold,⁶ and ventilatory responses to hypoxia and hypercarbia.⁷ A number of pathological investigations have demonstrated tissue alterations in the . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Pathology, The Ohio State University College of Medicine, Columbus. This article was begun by Dr Baba (now deceased) and finished posthumously.

Footnotes
Reprint requests to Department of Pathology, The Ohio State University, 4170 Graves Hall, 333 W Tenth Ave, Columbus, OH 43210 (Dr Quattrochi).

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