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Arrhythmias Associated With Sinus Node DysfunctionPathogenesis, Recognition, and Management
Martin A. Alpert, MD;
Greg C. Flaker, MD
JAMA. 1983;250(16):2160-2166.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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DURING the past 15 years, we have become increasingly aware of the importance of arrhythmias associated with sinus node dysfunction as a cause of cardiac and neurological symptoms. These arrhythmias currently afflict more than 100,000 Americans, and as a group constitute the most common indication for permanent cardiac pacemaker implantation. The objectives of this review are (1) to discuss the pathogenesis and pathophysiology of arrhythmias associated with sinus node dysfunction, (2) to provide a clinical, electrocardiographic, and electrophysiological basis for their diagnosis, and (3) to discuss principles of management, including the use of the cardiac electrophysiology laboratory.
Anatomy and Pathophysiology
The sinus node is located in the posterior right atrial wall at the junction of the right atrium and superior vena cava.1 It consists of three types of cells: P cells, transitional cells, and Purkinje's cells.2,3 The P cells, which are located in the midst of a collagen
. . . [Full Text PDF of this Article]
Author Affiliations
From the Departments of Medicine, University of Missouri Health Sciences Center and Harry S Truman Memorial Veterans Hospital, Columbia. Dr Alpert was a Teaching and Research Scholar of the American College of Physicians.
Footnotes
Reprint requests to Room C-7, University of Missouri Health Sciences Center, 807 Stadium Rd, Columbia, MO 65212 (Dr Alpert).
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