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Preliminary Report on Its Localization, Extraction and Partial Purification, and Action in Test Animals

Edgar Allen, Ph.D.; Edward A. Doisy, Ph.D.

JAMA. 1983;250(19):2681-2683.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The fact that double ovariectomy abolishes the cyclic changes which normally occur in the genital tract of female mammals demonstrates that these changes are due to some influence from the ovaries. That this influence is hormonal in nature is indicated by the maintenance of cyclic changes by autotransplantation of the ovaries to other sites in the body.¹ Many attempts have been made to localize the seat of production of an internal secretion in definite ovarian structures. The follicles, the corpora lutea² developing in them after ovulation, and the interstitial tissue³ have all been cited as possible sources, and many different ovarian preparations have been used clinically in the belief that therapeutic effects were being secured from accompanying hormones.

But there appears to be no conclusive evidence of either a definite localization of the hypothetic hormone or of the specific effect claimed for the commercial ovarian extracts in . . . [Full Text PDF of this Article]

Author Affiliations
St. Louis

From the Departments of Anatomy, Biologic Chemistry and Surgery, Washington University Medical School, St. Louis, with the assistance of Byron F. Francis, Harry V. Gibson, Leroy L. Robertson, Cleon E. Colgate and William B. Kountz.

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