This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (3)  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Arthur T. Hertig, MD

JAMA. 1983;250(19):2684-2688.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The term hormone was first coined in 1904 by W. M. Bayliss and C. H. Starling "for the active substances secreted into the blood stream or tissue fluids by the ductless or endocrine glands."¹ Adrenaline was the first hormone to be obtained in pure form from the medulla of the adrenal gland; watery extracts were obtained in 1894 by G. Oliver and E. H. Schafer; subsequently, J. J. Abel and A. C. Crawford in 1897 isolated an ester of the hormone — assumed to be the hormone itself — whereas in 1901, J. Takamine and B. Aldrich apparently succeeded in obtaining adrenaline itself in crystalline form, although it was shown later to be mixed with noradrenaline, a closely related hormone.¹

In 1902, Bayliss and Starling had discovered secretin, which is elaborated by the intestinal mucosa when stimulated by hydrochloric acid from the stomach. The hormone, thus obtained, when . . . [Full Text PDF of this Article]

Author Affiliations
From the Departments of Comparative Pathology, New England Regional Primate Research Center, Harvard Medical School, Southborough, Mass; and the Department of Pathology, Harvard Medical School, Boston.

Footnotes
Reprint requests to Harvard Medical School, 1 Pine Hill Dr, Southborough, MA 01772 (Dr Hertig).

A commentary on Allen E, Doisy EA: An ovarian hormone: Preliminary report on its localization, extraction and action in test animals. JAMA 1923;81:819-821.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?