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Human T-Cell Leukemia-Lymphoma Virus and Adult T-Cell Leukemia
William A. Blattner, MD;
Kiyoshi Takatsuki, MD;
Robert C. Gallo, MD
JAMA. 1983;250(8):1074-1080.
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THE ISOLATION and characterization of the human T-cell leukemia-lymphoma virus (HTLV)1-5 and its relationship to adult T-cell leukemia (ATL)6-8 represent the remarkable convergence of scientific discoveries made half a world apart. The discovery of HTLV represents the culmination of a search for a true human retrovirus (type C virus) that dates back more than 50 years. Almost simultaneous to this breakthrough was the remarkable recognition of a distinctive clinicopathologic entity, ATL.9-11 The molecular and clinical studies summarized in this review represent a scientific tale of two cities, Bethesda, Md, and Kyoto, Japan.
HTLV: A Prototype Human Retrovirus
In numerous animal species, naturally occurring leukemias or lymphomas are caused by retroviruses (also known as type C viruses, RNA tumor viruses, leukemia viruses).12-14 This class of virus is characterized by a replication cycle requiring integration of the viral genetic material in the form of a provirus into host
. . . [Full Text PDF of this Article]
Author Affiliations
From the Environmental Epidemiology Branch (Dr Blattner) and the Laboratory of Tumor Cell Biology (Dr Gallo), National Cancer Institute, Bethesda, Md; and the Second Department of Internal Medicine, Kumamoto University, Kumamoto, Japan (Dr Takatsuki).
Footnotes
Reprint requests to Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20205 (Dr Gallo).
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