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Amin C. Halstead, MD; Amin A. Nanji, MD, FRCP(C)
Vancouver General Hospital Vancouver, British Columbia

JAMA. 1984;251(1):38-39.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Measurement of serum creatinine concentration is the best of the widely available clinical means of assessing glomerular function. However, there are a number of pitfalls that must be taken into account when evaluating glomerular filtration by creatinine level measurements.¹ One of these pitfalls is the spurious interference by a variety of endogenous and exogenous metabolites.² The interference by bilirubin in the measurement of serum creatinine levels has been recognized in the technical literature for several years^3-5; however, its clinical implication has received little or no attention. We describe a patient who had discordant values for serum creatinine during his hospital stay. We also investigated bilirubin interference with creatinine level measurement by various methods.

Report of a Case.—

A 34-year-old man with decompensated alcoholic cirrhosis experienced oliguria two days after admission to the hospital. Relevant laboratory findings included the following measurements in serum: sodium, 135 . . . [Full Text PDF of this Article]

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