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Failure of Activated Prothrombin Complex Concentrates in a Hemophiliac With an Anti-Factor VIII Antibody
Philip M. Blatt, MD;
Gilbert C. White II, MD;
Campbell W. McMillan, MD;
William P. Webster, DDS
JAMA. 1984;251(1):67.
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IN APPROXIMATELY 15% of patients with severe hemophilia A who receive multiple transfusions, anti— factor VIII antibodies develop (C. W. McMillan, MD, S. S. Shapiro, MD, J. Lazerson, MD, unpublished data, 1983). Control of hemorrhagic episodes in these patients is often difficult and unsatisfactory. Various methods of treatment have been developed for such patients.1,2 Most recently, activated prothrombin complex concentrates (PCCs) have been described as efficacious in controlling hemorrhage in patients with an inhibitor. Two preparations of activated PCC have been developed: Autoplex (anti-inhibitor coagulant complex) and FEIBA (factor eight inhibitor bypassing activity). In published trials, response to treatment with Autoplex for major and minor bleeds ranged from excellent to fair with no treatment failures,2 while FEIBA was judged to be effective in control of joint and muscle bleeding in 64% of treatment episodes.3 The purpose of this report is to describe the failure of Autoplex to
. . . [Full Text PDF of this Article]
Author Affiliations
From the Departments of Medicine (Drs Blatt and White), Pediatrics (Dr McMillan), Pathology (Drs Blatt and Webster), and Laboratory Medicine (Dr Blatt), and the Comprehensive Hemophilia Diagnostic and Treatment Center, University of North Carolina School of Medicine, Chapel Hill.
Footnotes
Reprint requests to Division of Hematology, University of North Carolina School of Medicine, 417 Clinical Sciences Bldg 229H, Chapel Hill, NC 27514 (Dr White).
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