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A Pathologic and Clinical Entity

Burrill B. Crohn, M.D.; Leon Ginzburg, M.D.; Gordon D. Oppenheimer, M.D.

JAMA. 1984;251(1):73-79.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

We propose to describe, in its pathologic and clinical details, a disease of the terminal ileum, affecting mainly young adults, characterized by a subacute or chronic necrotizing and cicatrizing inflammation. The ulceration of the mucosa is accompanied by a disproportionate connective tissue reaction of the remaining walls of the involved intestine, a process which frequently leads to stenosis of the lumen of the intestine, associated with the formation of multiple fistulas.

The disease is clinically featured by symptoms that resemble those of ulcerative colitis, namely, fever, diarrhea and emaciation, leading eventually to an obstruction of the small intestine; the constant occurrence of a mass in the right iliac fossa usually requires surgical intervention (resection). The terminal ileum is alone involved. The process begins abruptly at and involves the ileocecal valve in its maximal intensity, tapering off gradually as it ascends the ileum orally for from 8 to 12 inches (20 . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Mount Sinai Hospital.

Footnotes
Read before the Section on Gastro-Enterology and Proctology at the Eighty-Third Annual Session of the American Medical Association, New Orleans, May 13, 1932.

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