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Pathophysiological and Radiological Correlation

Glen W. Hartman, MD; Vincente E. Torres, MD; Gary F. Leago, MD; Byrn Williamson, Jr, MD; Robert R. Hattery, MD

JAMA. 1984;251(13):1734-1738.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ANALGESIC abuse is a leading cause of renal papillary necrosis and cortical interstitial nephritis. Salicylates in combination with either phenacetin or acetaminophen seem more likely to cause renal damage than any of these agents alone. A cumulative dose of 1 kg of one or more analgesics, injested daily or almost daily for more than two or three years, is considered the minimum necessary to produce the disease.^1,2

Analgesic nephropathy is a common cause of end-stage renal failure. In Australia, this entity continues to be the cause of renal failure in as many as 20% of patients being treated in long-term dialysis programs.^3,4 In the United States, the incidence is lower, ranging from 2% to 10% in various reports.^1,2

The clinical manifestations of this disease are nonspecific. Clinical problems initially observed may include gross hematuria, renal colic caused by the passage of renal tissue, urinary tract infection, hypertension, . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Diagnostic Radiology (Drs Hartman, Leago, Williamson, and Hattery) and the Division of Nephrology and Internal Medicine (Dr Torres), Mayo Clinic and Mayo Foundation, Rochester, Minn.

Footnotes
Reprint requests to Mayo Clinic, 200 First St SW, Rochester, MN 55905 (Dr Hartman).

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