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Lewis Glickman, MD
Brooklyn, NY

JAMA. 1984;251(20):2657-2658.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

This is in reference to the question of whether there are valid instances in which combined use of different antipsychotic agents is indicated, eg, chlorpromazine and haloperidol.¹

I don't believe that Kimball and Glass explained the rationale of many of the psychiatrists who combine antipsychotics and consequently have to defend this practice from reviewers whose guidelines label it an indicator of inappropriate prescribing. The guidelines are based on the statements of authorities in psychopharmacology cited by the respondents that combined use is "seldom indicated"² and has "no rational basis."³

My letter is intended to describe the rational basis for combined use and some of the indications. The indications are based on two facts. The first, mentioned by the respondents, is that many of the antipsychotics have different adverse effect profiles. The second, which they did not mention, is that the most frequent effects are . . . [Full Text PDF of this Article]

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