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Victor Herbert, MD, JD

JAMA. 1984;251(4):522-523.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

This classic of lucid exposition brought together the elegant series of prior studies published by Castle and his collaborators beginning in 1929 and demolished the recently expressed opposing view by Greenspon¹ that gastric juice worked alone as a hematopoietic factor. A half century later, this 1936 article remains a model of clear presentation of a series of straightforward observations to draw almost inescapable conclusions.

Elucidation of Pernicious Anemia

In 1822, Coombe had first described what was almost certainly pernicious anemia in a 47-year-old male patient with a "deadly pale color" who suffered from "a species of dyspepsia... probably owing to some disorder of the digestive and assimilative organs."²

In 1860, Austin Flint, Sr, "that remarkable American physician and teacher,"³ aware of the atrophy of the secretory glands of the stomach recently reported by Handfield Jones after microscopic examination of 14 human stomachs, remarked with respect to pernicious . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Medicine, State University of New York, Downstate Medical Center, Brooklyn; and the Hematology and Nutrition Laboratory, Veterans Administration Medical Center, Bronx, NY.

Footnotes
Reprint requests to 130 W Kingsbridge Rd, Bronx, NY 10468 (Dr Herbert).

A commentary on Castle WB, Ham TH: Observations on the etiologic relationship of achylia gastrica to pernicious anemia: V. Further evidence for the essential participation of extrinsic factor in hematopoietic responses to mixtures of beef muscle and gastric juice and to hog stomach mucosa. JAMA 1936;107:1456-1463.

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