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H. Houston Merritt, M.D.; Tracy J. Putnam, M.D.

JAMA. 1984;251(8):1062-1067.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Good results in the treatment of patients with convulsive seizures have been obtained by a variety of methods, such as medical treatment with bromides or barbituric acid compounds, the ketogenic diet, restriction of fluids, and the surgical excision of scars or irritable cortical foci. In spite of these various therapeutic means there are a great number of patients who are not relieved of their attacks or are helped only temporarily by treatment. The fact that treatment by anticonvulsant drugs is at present the most widely used and on the whole the most effective method of therapy suggested to us the possibility that a direct and systematic experimental search might reveal more potent and less sedative compounds. With this idea in mind we devised an experimental procedure¹ which would produce convulsive seizures in animals at a constant threshold and which would allow for a qualitative and roughly quantitative determination of . . . [Full Text PDF of this Article]

Author Affiliations
Boston

From the Neurological Unit, Boston City Hospital, and the Department of Neurology, Harvard Medical School.

Footnotes
Under the auspices of the Harvard Epilepsy Commission.

This study was aided by a grant from Parke, Davis & Co., Detroit.

Read before the Section on Nervous and Mental Diseases at the Eighty-Ninth Annual Session of the American Medical Association, San Francisco, June 17, 1938.

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