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Naproxen and Pneumonitis
Aldo Vincent Londino, Jr, MD;
Gary L. Wolf, MD;
John J. Calabro, MD;
Samuel J. Perrone, MD
St Vincent Hospital Worcester, Mass
JAMA. 1984;252(14):1853.
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To the Editor.—
The relationship between the use of drugs and pulmonary disease is being recognized with greater frequency. Approximately 5% of patients admitted to hospitals are there because of adverse reactions to drugs.1 With reference to the article "Pulmonary Infiltrates Associated With Naproxen,"2 the following case is reported in support of a hypersensitivity pneumonitis due to naproxen sodium.
Report of a Case.—
A 48-year-old woman had seropositive rheumatoid arthritis and a biopsy-proved diagnosis of "rheumatoid lung" seven years ago. She had right and left upper lobe pulmonary infiltrates, with prompt and complete resolution following therapy with prednisone, 60 mg daily.
Three years later she had pulmonary infiltrates while receiving naproxen sodium, 250 mg twice a day; a sputum examination at that time revealed clumps of eosinophils with a peripheral eosinophil count of 1,104/cu mm. Again, there was complete resolution following prednisone therapy. In February 1984, she was
. . . [Full Text PDF of this Article]
Footnotes
Edited by John D. Archer, MD, Senior Editor.
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