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Deirdre Herrington, MD; George L. Drusano, MD; Ulysses Smalls; Harold C. Standiford, MD
University of Maryland Hospital Baltimore

JAMA. 1984;252(21):2962.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Flucytosine causes a falsely elevated serum creatinine measurement when an analytic method using creatinine iminohydrolase is employed.¹ This enzymatic assay is being introduced into many hospital laboratories, replacing systems with which flucytosine did not interfere.

Report of a Case.—

A 53-year-old man with alcoholic cirrhosis and cryptococcal meningitis was receiving therapy with amphotericin B (0.3 mg/kg/day) and flucytosine (150 mg/kg/day). His serum creatinine level, which was 1.0 mg/dL prior to drug therapy, rose to 3.2 mg/dL on the fourth day of therapy. The dosing regimen was altered because of the possibility of amphotericin-related renal dysfunction and the consequent possibility of bone marrow toxic reaction from flucytosine. Serum creatinine values then fluctuated on a daily basis, with a high of 6.3 mg/dL, a low of 1.1 mg/dL, and a mean of 3.5 mg/dL. It was discovered that creatinine measurements were being determined on a Kodak Ektachem 400 . . . [Full Text PDF of this Article]

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