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Stanley G. Smith, PhD
Weems Community Mental Health Center Meridian, Miss

W. Marvin Davis, PhD
University of Mississippi University, Miss

JAMA. 1984;252(8):1010.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Among patients seen in recent months at the clinical service of a community mental health center, five young male patients (aged 14 to 19 years) gave a current or recent history of nonmedical parenteral use of a drug combination consisting of butorphanol and diphenhydramine hydrochloride. They described their intravenous (IV) drug self-administration practice as being of wide occurrence among young persons of east-central Mississippi. From multiple-dose (10-mL) vials of each drug, 1.5 mL of each solution (butorphanol, 2 mg/mL; diphenhydramine hydrochloride, 50 mg/mL) was mixed in a syringe and injected. Several such doses were commonly taken in succession until the desired state is achieved. For most patients, the first injection produced an "unusual sensation" in the abdomen. A second or third injection was usually required (ie, 6 to 9 mg of butorphanol with 150 to 225 mg of diphenhydramine hydrochloride).

As tolerance developed, patients reported, it was . . . [Full Text PDF of this Article]

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