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Charles M. Elkin, MD; Norman E. Leeds, MD
Montefiore Medical Center Bronx, NY

JAMA. 1985;253(23):3398.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply.—

While Denton et al offer a viable alternative, we believe our approach toward patients with AIDS who have intracranial lesions results in rapid diagnosis and therapy without any risk of surgical intervention. Diagnostic specificity depends on the roentgenographic appearance of toxoplasmosis in the AIDS population and the effectiveness of the therapeutic antibiotic trial. Patients must meet clinical criteria for AIDS. If the CT appearance is atypical or the lesions progress despite adequate therapy, biopsy is indicated.

While stereotactic guided-needle biopsy is relatively safe, the amount of tissue obtained is often small. If the specimen is not adequate, additional samples or an open biopsy may be required. In our early experience, biopsies were performed in all cases. Once the pattern of findings in AIDS was elucidated, we avoided possible hemorrhagic complications of biopsy. . . . [Full Text PDF of this Article]

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