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Caroline C. Waddell, MD; Carol M. Ashton, MD; James A. Brown
Baylor College of Medicine Veteran's Administration Medical Center Houston

JAMA. 1985;253(3):344.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Factor VIII inhibitors develop in patients with hemophilia A (factor VIII deficiency) in a reported incidence of 5% to 20%¹ and have also been described in a variety of immunologic disorders, in postpartum women, and in elderly patients with no apparent underlying disorders. Bleeding in the presence of factor VIII inhibitors may be severe and difficult to control. We describe a patient with ulcerative colitis and factor VIII inhibitor who developed substantial postoperative bleeding following emergency colectomy. Corticosteroids, human factor VIII concentrate, cyclophosphamide, and activated prothrombin complex concentrates were ineffective, but a highly purified porcine factor VIII concentrate did increase the factor VIII level. No adverse effects were attributed to the porcine factor VIII preparation.

Report of a Case.—

A 36-year-old man with ulcerative colitis developed persistent bleeding following colectomy. Partial thromboplastin time (PTT) was 58 s (control of 30 s). Factor VIII level was 12%. . . . [Full Text PDF of this Article]

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