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Relating Kidney and Adrenal

Harriet P. Dustan, MD

JAMA. 1985;253(4):567-568.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A REREADING of the LANDMARK ARTICLE by Conn et al¹ reprinted in the current issue of JAMA watered my nostalgia plant because it reminded me of the intense interest in the renin-angiotensin-aldosterone system that characterized that time. Knowing what we know now, we find it hard to realize that 20 years ago the clinical relationships of the kidney and the adrenal gland were far from clear. By that time the differentiation of primary and secondary aldosteronism had been established, but a way to discriminate between them was not available. Conn and colleagues showed the way with their demonstration that plasma renin activity was suppressed in patients with primary aldosteronism (which came to be known as "Conn's syndrome") in contrast to the secondary aldosteronism of renal artery stenosis in which it was elevated.

This demonstration was a fine example of "technology transfer," although not recognized as such at the time. . . . [Full Text PDF of this Article]

Author Affiliations
From the Cardiovascular Research and Training Center, University of Alabama in Birmingham.

Footnotes
Reprint requests to Cardiovascular Research and Training Center, University of Alabama in Birmingham, 1002 Ziegler Bldg, Birmingham, AL 35294 (Dr Dustan).

A commentary on Conn JW, Cohen EL, Rovner DR: Suppression of plasma renin activity in primary aldosteronism. JAMA 1964;190:213-221.

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