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Andrew J. Cohen, MD; John P. Mordes, MD; Lewis E. Braverman, MD
University of Massachusetts Medical School Worcester

F. Duane Blume, PhD
California State College Bakersfield

JAMA. 1985;253(6):776-777.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply.—

We appreciate the opportunity to reply to Drs Reed and Shakir, who question whether cold exposure during the Mt Everest expedition might account for our reported data. While we have no information about the subjects' core temperatures, we have no reason to believe that these were substantially reduced. All subjects were fully dressed and slept overnight in tents in sleeping bags. Serum samples were collected in a heated tent. Moreover, despite possible differences in ambient temperature between the altitudes of 5,400 and 6,300 m, there is no reason to believe that there were changes in core temperature. Nevertheless, our data show a progressive increase in urinary volume and serum osmolality over the range of the three altitudes studied. The absence of a concomitant increment in plasma or urinary vasopressin levels suggests interruption of the normal osmoregulatory system.

In this regard, the references cited by Drs Reed and Shakir . . . [Full Text PDF of this Article]

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