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G. Mahrle, MD; B. Thiele, MD; G. K. Steigleder, MD
University of Cologne Cologne, West Germany

JAMA. 1985;253(7):977.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

We read with interest the article by Resnick and co-workers,¹ who reported complete clearing of tumor-stage mycosis fungoides that was complicated by a herpes simplex infection after treatment with acyclovir. The authors believed that if acyclovir is found to be efficacious in treating certain patients with mycosis fungoides and if retroviruses are of importance in the etiology of this disease, a mechanism of drug action could be the inhibition of reverse transcriptase.

This report prompted us to treat two patients with tumor-stage mycosis fungoides with acyclovir as recommended by Resnick et al. The patients had skin tumors for three and four years, respectively, and had received x-ray, electron beam, and therapy with methoxsalen plus ultraviolet light. We administered acyclovir (Zovirax), 400 mg IV every eight hours for 12 days (daily dose, 18 to 20 mg/kg).

The patients were followed for 11 and 14 days. There was . . . [Full Text PDF of this Article]

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