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Y. Antero Kesaniemi, MD
University of Helsinki

Scott M. Grundy, MD, PhD
University of Texas Health Sciences Center Dallas

JAMA. 1985;253(7):978-979.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply.—

The multicompartmental analysis of isotope kinetic curves of VLDL TGs, according to the method of Zech et al,¹ provides a value for FCR of VLDL TG. The transport rate (production rate) of VLDL TG is obtained by multiplying the FCR by the total plasma pool of VLDL TG. All interpretations about pathogenic mechanisms must be based on the FCR and transport rate of VLDL TG.

We observed that patients with type 5 HLP had very low FCR of VLDL TG and a very high transport rate. They consequently had very high plasma levels of VLDL TG. Another group of patients with less severe hypertriglyceridemia (type 4 HLP) had a very high transport rate of VLDL TG and a relatively normal FCR. These individuals were called "overproducers" of VLDL TG. Another group with type 4 HLP had very low FCRs and normal transport rates. They were said to . . . [Full Text PDF of this Article]

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