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Robert B. Gibbons, MD; Judith A. Lindauer, MD
St Joseph Hospital Denver

JAMA. 1985;253(9):1259-1260.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

A greater incidence of hypersensitivity reactions to trimethoprim-sulfamethoxazole in patients with acquired immunodeficiency syndrome (AIDS) as compared with other populations has been reported. Although pentamidine appears to be less toxic in this setting, trimethoprim-sulfamethoxazole is considered by most authorities to be the drug of choice in the treatment of Pneumocystis carinii pneumonia. We have recently seen two patients who fulfilled the criteria for the diagnosis of AIDS and were successfully treated with trimethoprim-sulfamethoxazole after experiencing hypersensitivity reactions to this medication.

Report of Cases.—

CASE 1.—A 34-year-old homosexual man was admitted to the hospital with fever, weight loss, and bibasilar interstitial infiltrates. Transbronchial biopsy confirmed the presence of P carinii, and intravenous (IV) trimethoprim-sulfamethoxazole and acyclovir therapy was instituted. On the tenth day of therapy, the patient developed an erythematous, macular rash and a temperature of 37.8 °C. Diphenhydramine was given IV concurrently with each trimethoprim-sulfamethoxazole infusion, following . . . [Full Text PDF of this Article]

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