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Gordon B. Snider, MD; Shashi A. Gogate, MD
Ohio State University Columbus Lancaster-Fairfield Community Hospital Lancaster, Ohio

JAMA. 1985;253(9):1260-1261.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Hepatitis B vaccine usage has greatly increased since its approval by the Food and Drug Administration and published recommendation by the Centers for Disease Control in 1982.¹ Serious adverse reactions attributable to vaccination have not been published except for a recent case report of polyneuropathy associated with hepatitis B vaccine.²

We report a case of possible systemic reaction to hepatitis B vaccine. The patient presented with cephalalgia, fever, anorexia, and malaise and later demonstrated symptoms of polyneuropathy and cholestasis.

Report of a Case.—

A 59-year-old gynecologist in excellent health, an alcohol abstainer, administered the first dose (1.0 mL) of hepatitis B vaccine to his nursing staff and himself. Two weeks later the physician developed severe cephalalgia, chills, and fever (temperature, 39.5 °C). A complete blood cell count was obtained. The total white blood cell count was 5,200/cu mm, with neutrophils, 57%; lymphocytes, 32% (20% atypical); . . . [Full Text PDF of this Article]

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