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Jean-François Devars du Mayne, MD
Louis Mourier Hospital Colombes, France

JAMA. 1985;254(1):53-54.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

In their article entitled "Autopsy Findings in the Acquired Immune Deficiency Syndrome," Dr Welch and associates¹ always found hepatic lesions that were sinusoidal dilatations. As the pathogenesis of these lesions is not discussed by the authors, I would like to describe our very similar findings.²

We performed systematic liver biopsies in 20 patients with documented acquired immunodeficiency syndrome (AIDS). Eighteen of 20 biopsies yielded abnormalities that could be related to diverse opportunistic infections and consisted of granulomatous and/or necrotizing lesions. However, prominent vascular lesions were observed in seven of these cases, with sinusoidal dilatations in two, peliosis hepatis in four, and angiosarcomatous changes in one.

In the absence of a hepatic outflow obstruction, sinusoidal dilatations and peliosis hepatis are known to be associated with many hepatic and extrahepatic diseases.³ However, I speculate that the striking vascular changes found in these series could be directly . . . [Full Text PDF of this Article]

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