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David M. Reifler, MD
Michigan State University Blodgett Memorial Medical Center, Butterworth and St Mary's Hospital Grand Rapids

JAMA. 1985;254(18):2553.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

I read with interest the article by Tell and associates¹ regarding the clinical usefulness of the immunoperoxidase technique for prostate-specific antigen in the diagnosis of atypical metastasis from prostate cancer. This excellent article again brought to our attention the value of special histochemical techniques. I would only like to add that atypical metastasis from prostatic carcinoma may also be confirmed using immunoperoxidase techniques on cytological specimens obtained by fine-needle aspiration. Use of this technique was reported by Reifler and associates² in a case of orbital metastasis. Nadji³ also demonstrated the possibilities of concurrent application of immunoperoxidase techniques with diagnostic cytology, including the establishment of a prostate carcinoma in a cervical lymph node. Certainly, fine-needle aspiration does not exclude the use of immunoperoxidase techniques and should be considered in selected cases, when an open biopsy would involve an extensive surgical procedure. . . . [Full Text PDF of this Article]

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