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D. Podzamczer, MD; L. Carreras, MD; E. Condom, MD; J. M. Baucells, MD; A. Vidaller, MD
Hospital de Bellvitge University of Barcelona Barcelona, Spain

JAMA. 1985;254(18):2554-2555.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Microangiopathic hemolytic anemia (MAHA) may be found to be associated with several entities, including hemolytic uremic syndrome (HUS), thrombotic thrombocytopenic purpura, and cancer.¹ We describe a patient who, together with having familial antecedents of HUS, presented with MAHA and adenocarcinoma of the lung. Pathology findings suggested the carcinoma to be related to the pathogenicity of the microangiopathic anemia. To our knowledge, this is the first description of the unusual association of familial HUS with MAHA and carcinoma.

Report of a Case.—

A 35-year-old man had familial antecedents of HUS. His son, sister, and niece had relapsing familial HUS, and all three, as well as our patient and a brother, had HLA haplotype A3,B7 with persistent hypocomplementemia through alternative pathway activation. Forty days before admission to hospital the patient became ill with sustained fever and discomfort in the lower right side of the jaw and lost 12 . . . [Full Text PDF of this Article]

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