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Successful Management With Immunoglobulin Infusion

Virgil L. Rose, MD; Leo I. Gordon, MD

JAMA. 1985;254(18):2626-2628.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IMMUNE thrombocytopenic purpura (ITP) is a syndrome of persistent thrombocytopenia resulting from antibody-induced destruction of platelets. Since it occurs most commonly in women during their reproductive years, ITP and pregnancy may be concomitant. We present a case of ITP during pregnancy, with an initial response to steroids that later became refractory, necessitating an alteration in therapy.

Report of a Case

A 30-year-old woman, gravida 3, para 2, was found to have thrombocytopenia on her first prenatal visit. She had no history of bleeding or bruising. On physical examination, there was no lymphadenopathy or hepatosplenomegaly. She had petechiae on her lower extremities. The white blood cell count was 12,200/cu mm; hemoglobin level, 13.5 g/dL; hematocrit, 40.6%; and platelet count, 33,000/cu mm. A peripheral blood smear had markedly decreased platelets with occasional giant forms. The bone marrow aspiration had increased megakaryocytes. Platelet-associated IgG antibody level was measured at 62 femtograms (fg)/platelet (normal, . . . [Full Text PDF of this Article]

Author Affiliations
From the Section of Hematology/Oncology and Hematology and the Cancer Center, Department of Medicine, Northwestern University Medical School, Chicago.

Footnotes
Reprint requests to Section of Hematology/ Oncology and the Cancer Center, Northwestern University Medical School, 303 E Chicago Ave, Chicago, IL 60611 (Dr Gordon).

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