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Successful Treatment With Pancuronium

Rahul Sangal, MD; Rodoljub Dimitrijevic, MD

JAMA. 1985;254(19):2795-2796.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

NEUROLEPTICS are useful medicines widely used to control psychosis and agitation. They have numerous side effects, including little-understood ones such as tardive dyskinesia and neuroleptic malignant syndrome (NMS). The latter is a rare side effect of most neuroleptics, including haloperidol, fluphenazine decanoate, and chlorpromazine. The occurrence of NMS does not seem to be related to dose or drug interactions. It is more likely to occur in young men, patients with brain disorders, and persons treated with depot-injection preparations, while heat stress, physical exhaustion, or dehydration may predispose to the syndrome.^1-3 Findings include hyperpyrexia, rigidity, dysphagia, dyskinesia, akinesia, delirium, sialorrhea, tachypnea-dyspnea, tachycardia, labile hypertension, cardiac arrhythmias, elevation in creatine kinase and liver function values, and respiratory acidosis.³ Death rates range from 20% to 38%, and death may occur because of complications such as cardiac arrhythmias, myocardial infarction, thromboembolism, aspiration pneumonia, respiratory failure, and rhabdomyolysis with myoglobinuria and acute renal . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Psychiatry, Wayne State University, Detroit (Dr Sangal); the Departments of Psychiatry (Dr Sangal) and Cardiology (Dr Dimitrijevic), St Joseph Hospital, Mount Clemens, Mich; and the Psychiatric Center of Michigan Hospital, New Baltimore (Drs Sangal and Dimitrijevic).

Footnotes
Reprint requests to Psychiatric Center of Michigan Hospital, 35031 23 Mile Rd, New Baltimore, MI 48047 (Dr Sangal).

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