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William G. Walter-Ryan, MD; Edward E. Kern III, MD; John R. Shirriff, MD; Julian M. Thomas, MD
University of Alabama School of Medicine Birmingham

JAMA. 1985;254(3):357-358.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Cutaneous reactions to tricyclic antidepressant drugs include acneiform eruptions, seborrheic dermatitis, contact dermatitis, nonspecific pruritic eruptions, urticaria, and photosensitivity reactions.^1,2 Most of these conditions are benign and self-limited. Although transient photosensitivity reactions have been documented with tricyclics, as well as with the structurally related phenothiazines,³ persistent light-sensitive cutaneous reactions seem to be rare. We report a case of severe, persistent cutaneous photosensitivity induced by imipramine.

Report of a Case.—

A 38-year-old physically healthy white woman was treated with the tricyclic doxepin for symptoms of depression and anxiety occurring two years prior to the present illness. A transient rash appeared following the first dose and this drug was discontinued. Treatment with the tetracyclic antidepressant maprotiline and a benzodiazepine was uneventful.

Four days prior to this admission, imipramine, 75 mg at bedtime, was prescribed after a long medication-free interval. The morning after the second dose, the patient . . . [Full Text PDF of this Article]

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