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Ross R. Bailey, MD, FRACP, FRCP
Christchurch Hospital Christchurch, New Zealand

JAMA. 1985;254(8):1034.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

I read with interest the article by Dr Hooton et al¹ entitled "Single-Dose Therapy for Cystitis in Women: A Comparison of Trimethoprim-Sulfamethoxazole, Amoxicillin, and Cyclacillin." As an enthusiast for single-dose antimicrobial therapy for uncomplicated acute bacterial cystitis in women, I was not particularly surprised with the results obtained with amoxicillin and a close relative of this drug, cyclacillin. It is now clear that the results with single-dose penicillins and cephalosporins have not been as good as those following the use of a single dose of either co-trimoxazole (trimethoprim-sulfamethoxazole), trimethoprim alone, or an aminoglycoside. The inferior success rates reported with single-dose ampicillinamoxicillin or the cephalosporins may simply reflect the way these drugs act in killing bacteria within the urinary tract.

Unfortunately in the design of this prematurely stopped study by Hooton et al,¹ there was no group of patients receiving a conventional course of treatment (eg, . . . [Full Text PDF of this Article]

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