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Robert R. Redfield, MD; D. Craig Wright, MD; Phillip D. Markham, PhD; Syed Zaki Salahuddin, MS; M. G. Sarngadharan, PhD; Robert C. Gallo, MD
Walter Reed Army Institute of Research Walter Reed Army Medical Center Washington, DC National Cancer Institute Bethesda, Md

JAMA. 1986;255(13):1705-1706.

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Because AIDS has been diagnosed almost exclusively in members of "high-risk" groups, physicians often do not consider the diagnosis of HTLV-III infection in individuals who do not belong to these risk groups. We have looked for evidence of HTLV-III infection in all patients (of either sex) presenting to our infectious disease service with the appropriate signs or symptoms and also their sexual partners. This case-finding methodology is etiologically based and epidemiologically sound. Our report documented the occurrence of HTLV-III disease in non-drug-using heterosexual males and females, thus providing scientifically sound evidence for bidirectional heterosexual transmission. Our report did not purport to define the relative risk of infection that is associated with either multiple heterosexual contacts or prostitute contacts. In a heterosexual population, we suggested that the risk of infection with HTLV-III will be more likely in individuals with multiple sexual partners or in individuals whose sexual contacts (eg, . . . [Full Text PDF of this Article]

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