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Jeffrey M. Hoeg, MD; Richard E. Gregg, MD; H. Bryan Brewer, Jr, MD
National Heart, Lung, and Blood Institute National Institutes of Health Bethesda, Md

JAMA. 1986;255(21):2894-2895.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply.—

Drs Van Horn and Norenberg have raised interesting points in their responses to our recent report.¹ As Dr Van Horn indicates, the use of the recommended formula (LDL cholesterol =total cholesterol—[(triglycerides/5)+HDL cholesterol]) gives a value of 152.8 mg/dL for his blood lipid analysis. However, as indicated in Table 3 of our article, this LDL cholesterol concentration would not place him at moderate risk as he suggests. Therefore, these lipid values would not lead to the use of subsequent diet and drug algorithms. In addition, the LDL cholesterol levels are indeed often lower in hypertriglyceridemic patients since the triglyceride-rich, very low-density lipoprotein particles are not converted to triglyceride-poor, cholesterol-rich LDL particles. In fact, we have recently demonstrated that this particular equation is valid for lipid analyses that include triglyceride levels as high as 800 mg/dL.²

An additional question was related to the use of ratios in the . . . [Full Text PDF of this Article]

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