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Leroy C. Knodel, PharmD; Bruce A. Wachsman
University of Texas Health Science Center at San Antonio

William D. Linn, PharmD
Audie Murphy Veterans Aministration Hospital San Antonio, Tex

JAMA. 1986;255(3):324-325.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Tolmetin sodium, a nonsteroidal anti-inflammatory drug (NSAID), is widely prescribed for the treatment of inflammatory disorders and pain. Although gastrointestinal side effects of agents in this pharmacologic class are well known, untoward renal effects have been substantiated only in recent years. These effects include acute renal failure, chronic renal injury, nephrotic syndrome and interstitial nephritis, as well as alterations in water and electrolyte homeostasis.¹ Many are directly related to inhibition of prostaglandin synthesis in the kidney and readily resolve on discontinuing use of the drug. Proteinuria is noted in most cases of NSAID-induced renal dysfunction. We wish to report a case of pseudoproteinuria that was clearly related to administration of tolmetin.

Report of a Case.—

A 55-year-old man with a 20-year history of hypertension and a 15-year history of degenerative joint disease was seen in clinic on Dec 11, 1984. Laboratory evaluation revealed a serum creatinine . . . [Full Text PDF of this Article]

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