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JAMA. 1986;256(10):1333-1337.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Therapeutic plasmapheresis, or therapeutic plasma exchange (TPE), is a method for removing toxic elements from the blood. It is performed by removing blood, separating the plasma from the formed elements, and reinfusing the formed elements together with a plasma replacement.

Therapeutic plasma exchange has been used to remove unwanted substances from the blood. These include toxins, metabolic substances, and plasma constituents implicated in disease, such as complement or antibodies. The ability to remove antibody and other immunologically active substances from the blood has led to the use of TPE as a therapy for neurological conditions in which autoimmunity is believed to play a role. It is estimated that half of the 20 000 to 30 000 TPE procedures performed annually at present in the United States are done on patients with neurological disorders.

Reports regarding use of TPE in the medical literature have generated both enthusiasm and controversy. Clinical trials . . . [Full Text PDF of this Article]

Footnotes
From the Office of Medical Applications of Research, National Institutes of Health, Bethesda. Md.

Reprint requests to Office of Medical Applications of Research, Bldg 1, Room 216, National Institutes of Health, Bethesda, MD 20205 (Michael J. Bernstein).

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