
Eflornithine Treatment of Pneumocystis carinii Pneumonia in AIDS
Thomas M. Gilman, PharmD;
Yana J. Paulson, PharmD;
C. Thomas Boylen, MD;
Peter N. R. Heseltine, MB;
Om P. Sharma, MD
University of Southern California Schools of Medicine and Pharmacy Los Angeles
JAMA. 1986;256(16):2197-2198.
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To the Editor.—
We have treated Pneumocystis carinii pneumonia (PCP) with the investigational drug eflornithine ( -difluoromethylornithine) in ten patients with acquired immunodeficiency syndrome (AIDS). Eflornithine irreversibly inhibits ornithine decarboxylase and prevents the biosynthesis of putrescine and other polyamines neces
. . . [Full Text PDF of this Article]
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