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Renato Candrina, MD; Gianni Giustina, MD

JAMA. 1986;256(21):2998-3000.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE OCCURRENCE of partial necrosis of a pituitary adenoma is a wellknown phenomenon, originally observed by Bleibtreu¹ in a patient with acromegaly. It has been aptly termed pituitary apoplexy² and has been reported to take place in approximately 10% of affected patients.^3,4 Its occurrence in acromegalic patients has been recorded more than 40 times, and clinical signs of acromegaly were always present beforehand.^4-8 An apparent spontaneous cure of acromegaly, with remission of acromegalic features after the apoplectic episode, occurs frequently,^6,8 but a recurrence of acromegaly, after a long period of clinical inactivity of disease following an episode of pituitary apoplexy, has also been described.⁷

We describe a young woman who presented after the spontaneous occurrence of pituitary apoplexy and had had a previously unsuspected, endocrinologically silent pituitary tumor excised by transsphenoidal approach. Pituitary functions partially recovered, but three years later she experienced the recurrence . . . [Full Text PDF of this Article]

Author Affiliations
From the Istituto di Patologia Medica, Universitá di Brescia (Italy).

Footnotes
Reprint requests to Istituto di Patologia Medica, Universitá di Brescia, 2a Medicina, Spedali Civili, 25100 Brescia, Italy (Dr Giustina).

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